GOOD HEALTH AND WELL-BEING

Conventional compound libraries are predominantly constructed via sp²–sp² cross-coupling and condensation reactions, leading to a prevalence of planar molecules centered around (hetero)aromatic rings. [...]

Neurons in the brain create a function by transmitting information across multiple brain regions. Therefore, it is essential to observe interregional projections in order to understand brain function. [...]

Brain macrophages, including microglia and CNS border-associated macrophages (CAMs), share a common developmental origin. However, the mechanisms maintaining their functions within specific local envi [...]

Neurological impairments following stroke are caused by inflammation and demyelination, but their detailed molecular mechanisms remain unclear. I have discovered an anti-sulfatide antibody that promot [...]

There are tumor immunity-based therapies such as immune checkpoint inhibitors like PD-1 antibodies in the treatment of oral squamous cell carcinoma. Immune checkpoint inhibitors mainly target T cells [...]

This study aims to elucidate the mechanism of cancer development from the perspective of cell biomechanics, with a particular focus on annexin, a protein whose expression is increased in cancerous tis [...]

Identification of endogenous ligands for human bitter taste receptor hT2R46 expressed throughout the human body by in silico and in vitro analyses

Department of Dental Science, Graduate School of Dental Science

Bitterness, one of the five basic tastes, is perceived by bitter taste receptors (T2Rs) with 25 members in humans, and is used to avoid intaking poisons and toxic substances. Recently, it has been rep [...]

Elucidation of the Mechanism Underlying Drug-Induced Osteonecrosis of the Jaw Caused by Chronic Peri-implantitis and the Establishment of Preventive Measures

Department of Dental Science, Graduate School of Dental Science

With population aging, more patients receive antiresorptive drugs, increasing MRONJ risk, especially in those with prior implants. MRONJ is now linked mainly to drug accumulation and chronic oral infl [...]

Construction of a sugar-amino acid hybrid scaffold with a unique 3D architecture

Multiplexed mapping of inter-regional projections using fluorescent barcode vectors

Understanding of the brain macrophages by focusing on lipid metabolism

Identification of autoantibodies with therapeutic effects on stroke

Research on the roles of B cells in tumor immunity of oral squamous cell carcinoma and tumor antigen identification

Elucidation of the carcinogenesis mechanism by changes in annexin localization under mechanical stimulation

Identification of endogenous ligands for human bitter taste receptor hT2R46 expressed throughout the human body by in silico and in vitro analyses

Elucidation of the Mechanism Underlying Drug-Induced Osteonecrosis of the Jaw Caused by Chronic Peri-implantitis and the Establishment of Preventive Measures

“Future-Creation (MIRAI)” Course Kyushu University SPRING program