The number of people with metabolic disorders such as obesity and diabetes has increased worldwide, leading to a higher risk of complications and rising healthcare costs. This suggests that our metabo [...]
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Functionalization of aliphatic residues in peptides is one of the most challenging issues in synthetic organic chemistry. We have developed a new method for regioselective C(sp3)–H functionalization u [...]
The intracellular DNA is constantly oxidatively damaged by reactive oxygen species and reactive nitrogen species, producing various oxidatively damaged bases. It is thought that when damage occurs at [...]
As drugs with high therapeutic efficacy and minimal side effects, therapeutic antibodies are widely used throughout the world. However, therapeutic antibodies have been reported to produce ADAs, which [...]
Phospholipids that constitute biological membranes are easily oxidized to form oxidized phospholipids. These oxidized phospholipids exhibit a variety of physiological activities and are known to be in [...]
The intracellular protein Protein Kinase C (PKC) plays a role in important cell functions such as cell migration, proliferation, and gene expression. It is known that these functions work not only in [...]
Fibrosis is a state of excessive accumulation of extracellular matrix such as collagen. Fibrosis is induced by cells called myofibroblasts, which are rarely found in normal tissues. Fibrosis is observ [...]
In recent years, because lifestyle diseases such as obesity and hypertension are spreading immediately, health trend is increasing on a global scale. Thus, food products are becoming more health-orien [...]