GOOD HEALTH AND WELL-BEING

Elucidation of the Mechanism Underlying Drug-Induced Osteonecrosis of the Jaw Caused by Chronic Peri-implantitis and the Establishment of Preventive Measures

Department of Dental Science, Graduate School of Dental Science

With population aging, more patients receive antiresorptive drugs, increasing MRONJ risk, especially in those with prior implants. MRONJ is now linked mainly to drug accumulation and chronic oral infl [...]

The aging of patients undergoing surgery has made it a challenge to deal with postoperative complications. In Japan, perioperative oral management was covered by national health insurance in 2012, but [...]

Regulation of Immune Function Activation by Oxygen Plasma Irradiation in Co-cultured Immune Cell Systems

Department of Interdisciplinary Engineering Science, Interdisciplinary Graduate School of Engineering Sciences

Conventional immunotherapy activates only a single type of immune cell, making it difficult to achieve sufficient therapeutic effects due to the lack of coordination within the complex immune system. [...]

This research aims to elucidate the mechanism of durotaxis and derive the equation of motion for cells. Cells generate forces spontaneously and move through interactions with the substrate, but the re [...]

The progress of regenerative medicine has been remarkable. Regenerative techniques using undifferentiated stem cells such as embryonic stem cells and iPS cells are attracting attention. Even in the fi [...]

Cancer-associated fibroblasts (CAFs) occupy the majority of a tumor’s microenvironment in Pancreatic Cancer. These cells contribute to the aggressive behavior of cancer cells, and confer resistance to [...]

近年、エクソン領域やイントロン領域の変異が新規スプライス部位を形成し、転写産物に異常なエクソンが挿入されて、疾患を引き起こすという報告がある。しかし、このスプライス部位形成変異（splice-site-creating mutation: SCM）は、遺伝性疾患の原因として散発的に報告されているだけで、実際に疾患に関与するSCMがどの程度存在するかについては明らかにされていない。そこで、私は、バイ [...]

Even the simplest of living cells are complex biological machines. This makes figuring out the physical principles behind many of the processes that occur inside them incredibly difficult. To solve th [...]

Elucidation of the Mechanism Underlying Drug-Induced Osteonecrosis of the Jaw Caused by Chronic Peri-implantitis and the Establishment of Preventive Measures

Perioperative oral management for prevention of postoperative complications

Regulation of Immune Function Activation by Oxygen Plasma Irradiation in Co-cultured Immune Cell Systems

Derivation of the equation of motion for cells through the elucidation of the mechanism of durotaxis

Elucidation of the mechanism of ameloblast differentiation and polarization regulation by cell junction factors

Research on the role of CAFs population and its impact on PDAC progression.

遺伝性疾患の原因となるスプライス部位形成変異の疾患横断的探索

Study of intracellular active gels by artificial cell reconstitution: from cellular dynamics to multicellular order

“Future-Creation (MIRAI)” Course Kyushu University SPRING program