GOOD HEALTH AND WELL-BEING

本研究では、膵 β 細胞における XAF1 が膵島機能および糖尿病の病態に及ぼす影響について、主に in vivo で検証した。高脂肪食負荷における、膵島マクロファージ由来 IFNβ を介した β 細胞 XAF1 発現の増大は、β 細胞のアポトーシス亢進を介して、インスリン分泌を減弱させ糖尿病の増悪に関与した。本研究結果から、高脂肪食誘導性の膵 β 細胞 XAF1 発現と糖尿病の病態悪化の関連性が [...]

　Medication-related osteonecrosis of the jaw (MRONJ) is one of the main side effects of bisphosphonates (BP) used in the treatment of osteoporosis and cancer, and its main symptom is intractable osteo [...]

Development of novel therapies for treatment-related myeloid tumors that develop after treatment for BRCA1 or BRCA2 mutation-positive ovarian cancer

Department of Medical Sciences, Graduate School of Medical Sciences

Ovarian cancer is the disease with poor prognosis among gynecologic malignancies, with a high recurrence rate and many patients receiving repeated chemotherapy. Patients with hereditary breast-ovarian [...]

n-3 polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA, 22:6n-3) and eicosapentaenoic acid (EPA, 20:5n-3) are mainly purified from marine fish oil, and used for medicines and supplem [...]

Spatial and non-spatial factors in the selection of childcare services by families with foreign origin

Department of Integrated Sciences for Global Society, Graduate School of Integrated Sciences for Global Society

This study focuses on the utilization of childcare services by families of foreign origin in Japan, recognizing that these services are crucial for supporting parents’ employment and child-reari [...]

Taste disorder, a distortion of the sense of taste, is partly caused by a variety of drugs associated with chronic diseases. Here, we focused on osteoporosis, which is a degenerative disease character [...]

Analysis of the mechanism of induction of autism spectrum disorder-like pathology by maternal immune activation and creation of a treatment method

Department of Medical Sciences, Graduate School of Medical Sciences

ASD is caused by genetic factors as well as by Maternal Immune Activation (MIA) such as maternal infection, however, the mechanism is unclear.We found that the expression of the cytokine IL-17a is inc [...]

To transmit genetic information to the next generation, accurate DNA replication of the entire genome is essential. However, the genome contains difficult-to-replicate regions, such as long repetitive [...]

膵 β 細胞 XAF1 が膵島機能及び糖尿病発症に及ぼす影響

A study on the effect of benidipine in MRONJ

Development of novel therapies for treatment-related myeloid tumors that develop after treatment for BRCA1 or BRCA2 mutation-positive ovarian cancer

Studies on synthetic mechanisms and physiological functions of n-3 PUFA in fish

Spatial and non-spatial factors in the selection of childcare services by families with foreign origin

Elucidation of the molecular mechanism of taste disorders derived from bisphosphonates.

Analysis of the mechanism of induction of autism spectrum disorder-like pathology by maternal immune activation and creation of a treatment method

Investigation of the Molecular Network of Replication Stress Response in Functional Long Repeat DNA Regions

“Future-Creation (MIRAI)” Course Kyushu University SPRING program