GOOD HEALTH AND WELL-BEING

好中球による自然免疫は病原体に対する最前線の生体防御機構であり、結核や急性呼吸窮迫症候群の病態形成にも関与する。ヒト好中球の自然免疫は、糖脂質ラクトシルセラミド（LacCer）により制御される。近年、LacCerの細胞膜上のクラスターが免疫反応のシグナル伝達に重要であることが明らかになった。本研究では、細胞内のC24-LacCerの挙動追跡や、相互作用しているタンパク質の同定を可能とする分子プロー [...]

Conventional compound libraries are predominantly constructed via sp²–sp² cross-coupling and condensation reactions, leading to a prevalence of planar molecules centered around (hetero)aromatic rings. [...]

Neurons in the brain create a function by transmitting information across multiple brain regions. Therefore, it is essential to observe interregional projections in order to understand brain function. [...]

Neurological impairments following stroke are caused by inflammation and demyelination, but their detailed molecular mechanisms remain unclear. I have discovered an anti-sulfatide antibody that promot [...]

There are tumor immunity-based therapies such as immune checkpoint inhibitors like PD-1 antibodies in the treatment of oral squamous cell carcinoma. Immune checkpoint inhibitors mainly target T cells [...]

This study aims to elucidate the mechanism of cancer development from the perspective of cell biomechanics, with a particular focus on annexin, a protein whose expression is increased in cancerous tis [...]

Identification of endogenous ligands for human bitter taste receptor hT2R46 expressed throughout the human body by in silico and in vitro analyses

Department of Dental Science, Graduate School of Dental Science

Bitterness, one of the five basic tastes, is perceived by bitter taste receptors (T2Rs) with 25 members in humans, and is used to avoid intaking poisons and toxic substances. Recently, it has been rep [...]

The aging of patients undergoing surgery has made it a challenge to deal with postoperative complications. In Japan, perioperative oral management was covered by national health insurance in 2012, but [...]

代謝耐性型ラクトシルセラミドプローブの開発と自然免疫機構解析への応用

Construction of a sugar-amino acid hybrid scaffold with a unique 3D architecture

Multiplexed mapping of inter-regional projections using fluorescent barcode vectors

Identification of autoantibodies with therapeutic effects on stroke

Research on the roles of B cells in tumor immunity of oral squamous cell carcinoma and tumor antigen identification

Elucidation of the carcinogenesis mechanism by changes in annexin localization under mechanical stimulation

Identification of endogenous ligands for human bitter taste receptor hT2R46 expressed throughout the human body by in silico and in vitro analyses

Perioperative oral management for prevention of postoperative complications

“Future-Creation (MIRAI)” Course Kyushu University SPRING program