細胞増殖を運命づける染色体DNA複製開始の分子機構の解析 Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences 抗菌剤が効かない薬剤耐性菌は世界的に問題となっている。この克服のためには、新たな抗菌薬の標的を探す必要がある。しかし、抗菌剤の新規標的が見つからないために新規抗菌薬の承認数は年々低下している。我々はこの新たな標的として染色体DNA複製の開始反応が有望であると考えた。本研究は分子生物学的手法および構造解析を用いることで、染色体DNA複製開始反応を分子レベルで理解する。
Elucidating the niche mechanisms that regulate intestinal macrophage diversity Department of Medical Sciences, Graduate School of Medical Sciences Intestinal immune homeostasis is maintained by multiple functions, such as immune responses, immune tolerance, barrier maintenance and tissue repair. These functions are supported by immune cells that [...]
History of Interaction between Jewish Immigrants and Anarchists in the 20th-Century West Department of History and Geography, Graduate School of Humanities I specialize in modern and contemporary European and American history. In particular, I examine migration, anarchist movements, and social movements beyond the framework of the nation-state. More spec [...]
Association Between Loss of Occlusal Support and Pneumonia Risk : Toward a Dental Preventive Intervention Model Department of Dental Science, Graduate School of Dental Science Japan’s aging society has made pneumonia and dementia major public health concerns. This study focuses on occlusal support as a functional indicator of oral health and investigates its association wit [...]
Engineering Chimeric Cytokine Receptor-Expressing Macrophages for Solid Tumor Therapy Department of Systems Life Sciences, Graduate School of Systems Life Sciences I am developing genetically modified macrophages for the treatment of solid tumors. Solid tumors survive within the body by creating a “suppressive immune environment”—a unique environment that preven [...]
Unraveling the control mechanism of “re-gripping behavior” in the praying mantis with 3D-motion analysis and stress analysis Department of Systems Life Sciences, Graduate School of Systems Life Sciences Bimanual movement requires the coordinated and complex activity of numerous muscles. Among animals capable of this type of movement, the praying mantis can display flexible foreleg movement which comp [...]
The Synthesis of Unsymmetric Triheteroaryl Diamines Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences Our laboratory has been committed to the research of Rhodium-catalyzed synthesis of organoheteroatom compounds and their functions. The previous work of our laboratory was unsymmetirc bicyclic linked [...]
Epigenetic effect of interferon-gamma and tumor necrosis factor-alpha on cholangiogenesis Department of Dental Science, Graduate School of Dental Science My research aims to elucidate the pathogenic mechanisms of biliary atresia (BA) by investigating the epigenetic impact of TNFA and IFNG on stem cells from human exfoliated deciduous teeth (SHED). Spec [...]
