Harmonicity of circadian rhythms Department of Design, Graduate School of Design Circadian rhythms have traditionally been analyzed using period, phase, and amplitude, while the “shape” of waveforms has been overlooked. This study uses curvature from differential geome [...]
Development of novel therapeutic strategy for treatment of neuropathic pain based on a new pain suppression mechanism Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences Neuropathic pain is intractable pain caused by damage to peripheral nerves and is characterized by hyperalgesia, in which even mild tactile stimuli, such as clothing touching the skin, cause severe pa [...]
Role of histone acetylation by HBO1 in origin licensing Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences The initiation of human DNA replication is regulated by “licensing” of the replication origin. Licensing involves the action of ORC, Cdc6, and Cdt1, and the loading of the DNA helicase, MC [...]
Exploration of estrogen-deficiency osteoclast precursor cell and target molecule for osteoporosis Department of Dental Science, Graduate School of Dental Science Postmenopausal women have deficiency of estrogen. It causes osteoporosis by bone loss which is high risk of bone fracture. Estrogen signal is against the signal of NF-κB that regulating factor of met [...]
中学校における小集団を対象としたストレスマネジメント教育の実践的研究 Department of Clinical Psychology and Community Studies, Graduate School of Human-Environment Studies 生徒の学校不適応が課題となっている中学校におけるストレスマネジメント教育（SME）に関する実践研究である。実際の中学校における，学習に対する不適応感を抱く生徒小集団を対象としたプログラムの実践により，一定のストレス反応尺度低減の効果が確認された。加えて，プログラムに関する教員へのインタビュー調査により，教員から見たプログラムの効果および，今後のプログラム実践についての課題が明らかとなった。
Functions of CNS Border-Associated Macrophages in Development and Pathological Conditions Department of Medical Sciences, Graduate School of Medical Sciences The central nervous system (CNS) hosts several macrophages, which include microglia that occupy the parenchyma of the brain, and CNS border-associated macrophages (CAMs) that are found at the border, [...]
Development of a Sequential Click-Reactive Molecular Platform for the Construction of Multifunctional Antibody–Drug Conjugates (ADC) Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences This study aims to develop a platform molecule compatible with antibodies that enables sequential click reactions. The developed platform will be utilized for the convergent synthesis of antibody-drug [...]
Quantum sensing using photoexcited triplet electron spin Department of Applied Chemistry, Graduate School of Engineering Quantum sensing, which uses the unique properties of quantum for sensing, is expected to surpass the theoretical limit of conventional sensing. Quantum sensing uses qubits, which extend the classical [...]
