Artificial transcriptional activation system for RNA detection Department of Systems Life Sciences, Graduate School of Systems Life Sciences Cells containing engineered gene circuit could become “biological machines” performing a vast range of useful functions such as responding to a given stimulus. Similar to cellular response [...]
Exploring the Effect of the Animal-Derived Sialic Acid Intake in Alzheimer's Disease Department of Dental Science, Graduate School of Dental Science In this study, we utilize CMAH-deficient (humanized) Alzheimer’s disease (AD) model mice, which are incapable of synthesizing Neu5Gc, and feed them a diet rich in Neu5Gc to simulate the metaboli [...]
Antitumor effect of NK-like cell(GAIA-102) on refractory tumors and its underlying mechanism Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences Our developed NK-like cells (GAIA-102) have exhibited antitumor therapeutic effects in vitro and in vivo, which rely on the host’s adoptive immunity. However, the underlying mechanism remains un [...]
The Mechanism of E-sports Addiction from the Perspective of Social Psychology Department of Behavioral and Health Sciences, Graduate School of Human-Environment Studies In recent years, e-sports has developed rapidly as a new form of video games. In now days, the e-sports population of Japan is growing. Some eductor want to introduce e-sports into campus, and there a [...]
Development of Unactivated C-C Bond Cleavage Reaction Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences C–C bond constructs the framework of organic compounds, thus C–C activation provides a powerful tool to approach organic synthesis by employing readily available and inexpensive raw materials from nat [...]
Investigating the mechanism of transcription termination defect in cancer cells Department of Medical Sciences, Graduate School of Medical Sciences Distinct gene expression patterns in cancer and normal cells have been revealed by high-throughput sequencing technologies that mainly profile cancer-specific transcription start site (TSS) usage. As [...]
The strategy to block the diabetes mellitus-dementia linkage by food compounds Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences Many epidemiological studies have shown the link between diabetes mellitus and dementia, strongly indicating that “diabetes mellitus is the risk factor of dementia”. However, there is no study of bloc [...]
Development of high-throughput drug discovery method using quantum chemical calculations Department of Interdisciplinary Engineering Science, Interdisciplinary Graduate School of Engineering Sciences In recent years, the development of new drugs has been difficult due to the cost of research and the time required for their commercialization. On the other hand, highly accurate drug discovery metho [...]
