GOOD HEALTH AND WELL-BEING

Epithelial cells have characteristic structures such as intercellular adhesion structures. Very long-chain fatty acid sphingomyelin(VLCFA-SM), which forms a dense and low-fluidity membrane regions, is [...]

抗菌剤が効かない薬剤耐性菌は世界的に問題となっている。この克服のためには、新たな抗菌薬の標的を探す必要がある。しかし、抗菌剤の新規標的が見つからないために新規抗菌薬の承認数は年々低下している。我々はこの新たな標的として染色体DNA複製の開始反応が有望であると考えた。本研究は分子生物学的手法および構造解析を用いることで、染色体DNA複製開始反応を分子レベルで理解する。

Our laboratory has been committed to the research of Rhodium-catalyzed synthesis of organoheteroatom compounds and their functions. The previous work of our laboratory was unsymmetirc bicyclic linked [...]

My research aims to elucidate the pathogenic mechanisms of biliary atresia (BA) by investigating the epigenetic impact of TNFA and IFNG on stem cells from human exfoliated deciduous teeth (SHED). Spec [...]

Towards Walkable city: Integrating Mobile Big Data and Built Environment Factors for a Multi-Dimensional Walkability Assessment in Japanese Cities

Department of Urban Design, Planning and Disaster Management, Graduate School of Human-Environment Studies

This study aims to integrate built environment factors and mobile phone big data to conduct a multi-dimensional walkability assessment in Tokyo’s 23 wards. Over the past few decades, walkability [...]

Food functional ingredients contribute to the prevention and alleviation of lifestyle and degenerative diseases and related molecular mechanism

Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences

The main research project of mine is functional food ingredients that contribute to the prevention and alleviation of lifestyle and degenerative diseases and related molecular mechanisms, mainly focus [...]

Plasma membrane Bleb is a hemispherical membrane projection structure composed of a plasma membrane membrane that is not lined by an actin cytoskeleton. Recently, it has become clear that cells that e [...]

タンパク質の特異的ラベル化は、その局在やタンパク質間相互作用の解析を可能とするライフサイエンス研究における重要な基盤技術である。本研究では、標的特異的な光ラベル化法を応用して、膜タンパク質の局在解析および関連タンパク質との相互作用解析を可能とする手法を確立した。今後、脳神経科学を専門とするオーストリアIST 研究所重本教授と連携し、光ラベル化を応用したグルタミン酸受容体の電子顕微鏡一分子局在解析、 [...]

Elucidation of the Mechanism by which Very Long-Chain fatty acid Sphingomyelin Maintains Membrane Homeostasis in Epithelial Cells

細胞増殖を運命づける染色体DNA複製開始の分子機構の解析

The Synthesis of Unsymmetric Triheteroaryl Diamines

Epigenetic effect of interferon-gamma and tumor necrosis factor-alpha on cholangiogenesis

Towards Walkable city: Integrating Mobile Big Data and Built Environment Factors for a Multi-Dimensional Walkability Assessment in Japanese Cities

Food functional ingredients contribute to the prevention and alleviation of lifestyle and degenerative diseases and related molecular mechanism

The Mechanism of Bleb Formation Involved in Amoeboid Cell Migration of Cancer Cells

特異的ラベル化を用いた膜タンパク質の高解像度局在・インターラクトーム解析応用

“Future-Creation (MIRAI)” Course Kyushu University SPRING program