Revealing the genetic mechanism of de novo mutation in population using the genome sequencing data of three-generation families. Department of Systems Life Sciences, Graduate School of Systems Life Sciences これまでの研究は、突然変異が生じる現象だけに注目してきたため、ゲノム進化過程の一面しかとらえていない。本研究では、個人に新たに生じた突然変異を同定し、変異の遺伝様式及び発生期間の推定を行い、ゲノム領域と変異の関連を明らかにすることで、新たに生じた変異が集団内に固定されていく遺伝的メカニズムの解明を試みた。
Elucidation of the membrane protein sorting mechanism that regulates organelle degradation. Department of Medical Sciences, Graduate School of Medical Sciences Autophagy is an intracellular degradation pathway that plays an important role in maintaining cellular homeostasis. Mitochondria are double-membrane bounded organelles that play a key role in regulati [...]
Development of personalized neurofeedback methods Department of Systems Life Sciences, Graduate School of Systems Life Sciences Neurofeedback (NF) technology, in which electroencephalogram (EEG) information is converted into audiovisual stimuli and presented in real time to self-regulate brain activity, is being increasingly a [...]
合成生物学的手法による肝機能誘導型ヘパトーマ細胞株の開発 Department of Chemical Systems and Engineering, Graduate School of Engineering 肝不全患者の肝機能を補助するバイオ人工肝臓システムや、創薬における化合物スクリーニングへの利用のために、高い肝機能を有した細胞を安定かつ大量に調製することが求められている。本研究では、肝機能は低いが増殖性の高い肝がん由来細胞株に肝臓の機能発現に寄与している肝特異的転写因子遺伝子と導入遺伝子の発現を制御するシステムを導入し、加温をスイッチとして高増殖状態から高肝機能発現状態へと切り替え可能な細胞株の [...]
Analysis of the role of Runx/Cbfβ in ILC3 maturation Department of Medical Sciences, Graduate School of Medical Sciences Gut is important for the absorption of water and nutrients. Additionally, it is a unique environment where the gut microbiota, the distinctive neural network known as the enteric nervous system, and n [...]
Development of a cell identification method by direct labeling of cells using "Human-Orthogonal-Enzymes” Department of Systems Life Sciences, Graduate School of Systems Life Sciences Cells express a wide variety of proteins, which are frequently used as markers to identify cells. Antibodies modified with fluorescent groups are commonly used to detect proteins, but sensitivity is o [...]
Identification of regulatory T cells in adenoid cystic carcinoma and elucidation of their immune mechanisms Department of Dental Science, Graduate School of Dental Science In this study, we aim to investigate the immunosuppressive environment in salivary gland adenoid cystic carcinoma (AdCC) through single-cell RNA sequencing and TCR repertoire analysis of tumour-infilt [...]
Identification of pathogenesis-related T cells in autoimmune diseases and creation of the world's first genetic database for new drug development Department of Dental Science, Graduate School of Dental Science Our research group has been elucidating the specific T cells that play a key role in the pathogenesis of autoimmune diseases (such as systemic sclerosis, Sjögren’s syndrome, and IgG4-related dis [...]
