GOOD HEALTH AND WELL-BEING

With the increasing ageing and various muscle diseases, more and more people are suffering from muscular weakness that makes them hard to cope with daily life. In order to solve this problem, we devel [...]

Sensory information from the periphery enters the spinal cord via primary afferents and is transmitted to the brain where it is perceived as various sensations. In the spinal cord, appropriate modific [...]

Allylic amines are ubiquitous, prevalent in various biologically active compounds, and essential as synthetic intermediates for many organic compounds. We reported the first direct catalytic amination [...]

As aging progresses, the deterioration of biological functions and homeostasis leads to a decrease in survival rate along with an increased risk of various diseases. Anti-aging research for extending [...]

Oxidized phospholipids, generated through membrane phospholipid oxidation, regulate diverse biological processes including cell death and inflammation, yet their targets remain largely unknown. Our la [...]

液性免疫応答は生体防御のメカニズムとして重要である。液性免疫の主役を担うのはB細胞であり、B細胞の小胞体恒常性維持がB細胞分化と抗体産生に密接に関与する。小胞体はタンパク質の品質管理と細胞質内Ca2+濃度の調節が主な機能として知られており、これら2つの機能を制御することが小胞体恒常性に重要である。そこで、この2つの機能調節に重要な分子に着目し、B細胞における機能解析を行う。これにより、液性免疫にお [...]

Aiming to develop for new genome editing tools, functional and structural studies of a novel Cas9 identified from hot spring

Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences

CRISPR-Cas9 is prokaryotic adaptive immune system against invading foreign DNAs and is applied to genome editing tools. Cas9 is an RNA-guided endonuclease and binds a guide RNA composed of CRISPR-RNA [...]

これまでの研究は、突然変異が生じる現象だけに注目してきたため、ゲノム進化過程の一面しかとらえていない。本研究では、個人に新たに生じた突然変異を同定し、変異の遺伝様式及び発生期間の推定を行い、ゲノム領域と変異の関連を明らかにすることで、新たに生じた変異が集団内に固定されていく遺伝的メカニズムの解明を試みた。

Study on soft 7-DoF upper-limb power-assist robots

Study of immune cell infiltration into the spinal cord associated with spinal canal stenosis and the development of leg pain

Convenient Direct Catalytic Synthesis of Primary Allylic Amines from Allylic Alcohols with Ammonium Acetate

Design and Synthesis of Prodrugs for Anti-aging

Elucidation of the signaling mechanism of oxidized phospholipid receptor using Cryo-EM

液性免疫応答における小胞体恒常性の生理学的役割

Aiming to develop for new genome editing tools, functional and structural studies of a novel Cas9 identified from hot spring

Revealing the genetic mechanism of de novo mutation in population using the genome sequencing data of three-generation families.

“Future-Creation (MIRAI)” Course Kyushu University SPRING program