GOOD HEALTH AND WELL-BEING

The number of people with metabolic disorders such as obesity and diabetes has increased worldwide, leading to a higher risk of complications and rising healthcare costs. This suggests that our metabo [...]

Functionalization of aliphatic residues in peptides is one of the most challenging issues in synthetic organic chemistry. We have developed a new method for regioselective C(sp3)–H functionalization u [...]

The intracellular DNA is constantly oxidatively damaged by reactive oxygen species and reactive nitrogen species, producing various oxidatively damaged bases. It is thought that when damage occurs at [...]

As drugs with high therapeutic efficacy and minimal side effects, therapeutic antibodies are widely used throughout the world. However, therapeutic antibodies have been reported to produce ADAs, which [...]

Elucidation of the biological effects of oxidized phospholipids based on the identification of oxidized phospholipid–responsive G protein–coupled receptors

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences

Phospholipids that constitute biological membranes are easily oxidized to form oxidized phospholipids. These oxidized phospholipids exhibit a variety of physiological activities and are known to be in [...]

The intracellular protein Protein Kinase C (PKC) plays a role in important cell functions such as cell migration, proliferation, and gene expression. It is known that these functions work not only in [...]

Fibrosis is a state of excessive accumulation of extracellular matrix such as collagen. Fibrosis is induced by cells called myofibroblasts, which are rarely found in normal tissues. Fibrosis is observ [...]

In recent years, because lifestyle diseases such as obesity and hypertension are spreading immediately, health trend is increasing on a global scale. Thus, food products are becoming more health-orien [...]

A novel role of citric acid cycle for metabolic disorders

Selective C(sp3)–H Functionalization of Aliphatic Amino Acids Residues in Peptides

Development of artificial nucleic acid that specifically recognizes oxidatively damaged bases and enables sequencing

Improvement of therapeutic antibodies based on CH2 domain

Elucidation of the biological effects of oxidized phospholipids based on the identification of oxidized phospholipid–responsive G protein–coupled receptors

Mechanism of activation of cPKC and nPKC in wound detachment of vascular endothelial cells

Identification of inhibitors of the secretory protein that promotes fibrosis

Research relating to the changes of miRNA expression in human blood and the function by intaking of food

“Future-Creation (MIRAI)” Course Kyushu University SPRING program