Development of carbene-transfer reaction using dihydrogen as electrons source Department of Applied Chemistry, Graduate School of Engineering カルベンは反応性の高い化学種であり、それを反応に利用するカルベン移動反応では様々な有機合成が可能である。一方で、取り扱いが難しく環境負荷が大きい試薬の使用が問題点であった。本研究では、そのような試薬の代わりに水素から電子を取り出して反応に利用する新たなカルベン移動反応を提案する。将来的な目的物として、医薬品や天然物の有機物、精密合成による生成物などが考えられ、大きな社会的インパクトが期待される。
In vitro reconstitution of the eukaryotic DNA mismatch repair in the context of chromatin Department of Systems Life Sciences, Graduate School of Systems Life Sciences DNA mismatch repair (MMR) is a mutation avoidance system that post-replicatively corrects nucleotide misincorporation errors. However, eukaryotic genomes are wrapped around histones to be assembled in [...]
Development of pharmaceutical protein production technology by transgenic chickens Department of Chemical Engineering, Graduate School of Engineering Animal cells such as Chinese hamster ovary (CHO) cells have been utilized as producer host cells for the production of pharmaceutical proteins. However, the culturing of these animal cells requires la [...]
Study on soft 7-DoF upper-limb power-assist robots Department of Mechanical Engineering, Graduate School of Engineering With the increasing ageing and various muscle diseases, more and more people are suffering from muscular weakness that makes them hard to cope with daily life. In order to solve this problem, we devel [...]
Establishing a method of dark matter detection using Two-level atom system Department of Physics, Graduate School of Science As a universal detection method for dark matter, I propose utilizing the energy dissipation phenomenon of a two-level atomic system in curved spacetime (i.e., in a gravitational field).It is well know [...]
Convenient Direct Catalytic Synthesis of Primary Allylic Amines from Allylic Alcohols with Ammonium Acetate Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences Allylic amines are ubiquitous, prevalent in various biologically active compounds, and essential as synthetic intermediates for many organic compounds. We reported the first direct catalytic amination [...]
Study of superconducting mechanism in palladium hydrides by controlling the lattice vibrations Department of Applied Quantum Physics and Nuclear Engineering, Graduate School of Engineering Palladium hydrides exhibit superconductivity at hydrogen concentrations above 0.8. The role of hydrogen atoms in the mechanism of hydride superconductivity will be clarified by microscopic measurement [...]
A Study on ASR Expansion of Concrete and its Prediction Method Department of Civil Engineering, Graduate School of Engineering コンクリートの劣化の一つであるアルカリシリカ反応（ASR）は，コンクリートの材料間の反応に由来し，致命的な膨張ひび割れを引き起こす。コンクリートごとに使用されるセメント・石・砂やその配調合が異なるため，ASRには画一的な対策が通用しない。そこで，各要因の影響度を把握するための膨張実験と，劣化メカニズム解明に向けた微視的観察を行い，数値的な予測モデルを提案することで，新たなインフラ設計・維持管理手法 [...]
