哺乳類ではたった一つの受精卵から個体が形成される。このように一つの細胞から一個体を形成できる能力を全能性といい、その性質を有する細胞を全能性細胞という。したがって全能性細胞は生命の源であり、その分子基盤を理解することは「生命とは何か」に対する知見をもたらす。本研究では着床前初期発生過程の細胞核を用いたプロテオーム解析から全能性制御に関与する要素の同定を目指す。
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DNA mismatch repair (MMR) is a mutation avoidance system that post-replicatively corrects nucleotide misincorporation errors. However, eukaryotic genomes are wrapped around histones to be assembled in [...]
Animal cells such as Chinese hamster ovary (CHO) cells have been utilized as producer host cells for the production of pharmaceutical proteins. However, the culturing of these animal cells requires la [...]
With the increasing ageing and various muscle diseases, more and more people are suffering from muscular weakness that makes them hard to cope with daily life. In order to solve this problem, we devel [...]
Sensory information from the periphery enters the spinal cord via primary afferents and is transmitted to the brain where it is perceived as various sensations. In the spinal cord, appropriate modific [...]
Allylic amines are ubiquitous, prevalent in various biologically active compounds, and essential as synthetic intermediates for many organic compounds. We reported the first direct catalytic amination [...]
As aging progresses, the deterioration of biological functions and homeostasis leads to a decrease in survival rate along with an increased risk of various diseases. Anti-aging research for extending [...]
液性免疫応答は生体防御のメカニズムとして重要である。液性免疫の主役を担うのはB細胞であり、B細胞の小胞体恒常性維持がB細胞分化と抗体産生に密接に関与する。小胞体はタンパク質の品質管理と細胞質内Ca2+濃度の調節が主な機能として知られており、これら2つの機能を制御することが小胞体恒常性に重要である。そこで、この2つの機能調節に重要な分子に着目し、B細胞における機能解析を行う。これにより、液性免疫にお [...]