当研究室では線維芽細胞に特定の転写因子を導入することでinduced Hepatocyte-like cells(iHep細胞)の作製に成功している。iHep細胞は肝細胞特有の機能を有したまま培養が可能であることから医療応用が期待されているが、詳細な誘導メカニズムは明らかになっていない。そこでリアルタイムに誘導過程の細胞分裂動態を観察できる解析システムを開発した。解析の結果、同じ細胞由来の細胞でも [...]
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Vection refers to the visual illusion of self-motion induced by a stationary observer (Right figure). Visual-spatial attention involves directing attention to a location in spatial. Some studies have [...]
The tongue microbiota is a major source of numerous oral microbial populations which we are swallowing, and its bacterial composition has been linked to the lung and gut health. However, it remains un [...]
Ameloblasts undergo complex morphological changes during differentiation from epithelial stem cells. The p130 Crk-associated substrate (Cas) is a scaffold protein that regulates cellular processes suc [...]
Flooding is a common natural disaster with high suddenness, high frequency, and wide coverage. Flooding and its associated impacts not only lead to great losses of life, but also disturb regional deve [...]
Alcohols, ethers, ketones, carboxylic acids and esters with chirality center (oxy-functionalized central chiral molecules) are important as bioactive compound, functional materials, and their syntheti [...]
Mesenchymal stem cell(MSC) is known as a tool for cell therapy. Notably, MSC-derived exosome plays a central role in therapeutics.We recently demonstrated that exosome from TNF-α treated GMSCs inhibit [...]
Voice disorders vary from organic diseases such as laryngeal cancer to functional diseases such as psychogenic aphonia. Voice disorders cause hoarseness specific to each disease. Therefore, voice qual [...]