GOOD HEALTH AND WELL-BEING

本研究の目的はタンパク質と共有結合を形成するコバレント阻害剤のための新しい反応化学の開拓と、その創薬応用である。コバレント阻害剤は強く持続する薬効を示す優れた特性を持つ。コバレント阻害剤の重要な特性は副作用に繋がるオフターゲット反応を起こさない標的特異性である。しかし、生体内で高い標的選択性を示す有用な反応化学の開拓は発展途上である。本研究ではタンパク質中のリジンと反応する新規反応基を開発し、高い [...]

上肢欠損者の日常生活動作向上のため、ロボット義手が開発されている。しかし現状では機構や制御方法の複雑さから詳細な指の動きは難しく、より人間に近い動作が可能なロボット義手が求められている。そこで本研究では人体の手の構造を模倣し関節を腱の張力で制御するロボット義手を開発する。これまでに1本指のロボットを健常者の筋電位を指令値とした制御に成功しており、今後義手としての使用を想定した指ロボットの制御手法を [...]

Phospholipids that constitute cell membranes are easily oxidized due to the presence of polyunsaturated fatty acids within molecules, leading to the formation of a wide variety of oxidized phospholipi [...]

Memory defines who we are as humans. Memory allows us to obtain information and skills and to recall past events. Scientists have been diving into understanding memory’s mechanisms and how memory was [...]

Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease characterized by recurrent pruritic pustules on the palms and soles, significantly impairing patients’ quality of life. While chron [...]

Nucleic acid delivery technologies such as lipid nanoparticles (LNPs) have spread worldwide as mRNA vaccine formulations for new coronavirus infections, and many researchers are still actively engaged [...]

Macrophages play an important role as the starting point of cancer immunity by phagocytosing cancer cells and causing activation of immune cells such as T cells and B cells. Our laboratory has previou [...]

DNA, the genetic material, is damaged by endogenous as well as exogenous sources such as base alkylating chemicals. Some alkylating reagents produce O-6-methylguanine (O6mG), which induces cell death, [...]

コバレント阻害剤に応用可能な新しい反応化学の開拓とその創薬応用

人体構造に準じたインテリジェントロボット義手の研究

Elucidation of the Novel Functions of Oxidized Phospholipids Focused on Protein Modification

The differences in the neural circuit pathways during fear memory acquisition and retrieval

Investigation of T Cell–Driven Immune Mechanisms in Palmoplantar Pustulosis and the Potential for Drug Repurposing

Pharmacokinetic analysis and cancer immunotherapy applications of lipid nanoparticle formulations using newly synthesized lipids.

Effects of novel phagocytosis-related enzymes in cancer immunity

In vitro analysis of mismatch-repair dependent processing of alkylated bases

“Future-Creation (MIRAI)” Course Kyushu University SPRING program