K-SPRING alumna ABE Masami’s (currently in the Faculty of Pharmaceutical Sciences, Kyushu University) paper has been accepted for publication in Redox Biology.
Congratulations!
Author(s)
Ryota Mori, Masami Abe, Yuma Saimoto, Ken-ichi Yamada and 15 others
Affiliation
Faculty of Pharmaceutical Sciences
Manuscript Title
Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases
Abstract
Recent studies have highlighted the indispensable role of oxidized lipids in inflammatory responses, cell death, and disease pathogenesis. Consequently, inhibitors targeting oxidized lipids, particularly lipid-derived radicals critical in lipid peroxidation, which are known as radical-trapping antioxidants (RTAs), have been actively pursued. We focused our investigation on nitroxide compounds that have rapid second-order reaction rate constants for reaction with lipid-derived radicals. A novel screening system was developed by employing competitive reactions between library compounds and a newly developed profluorescence nitroxide probe with lipid-derived radicals to identify RTA compounds. A PubMed search of the top hit compounds revealed their wide application as repositioned drugs. Notably, the inhibitory efficacy of methyldopa, selected from these compounds, against retinal damage and bilateral common carotid artery stenosis was confirmed in animal models. These findings underscore the efficacy of our screening system and suggest that it is an effective approach for the discovery of RTA compounds.
Journal name
Redox Biology
Relevant SDGs
3 Ensure healthy lives and promote well-being for all at all ages
Comments from Masami Abe
My name is Masami Abe and I am currently a postdoctoral fellow at the Faculty of Pharmaceutical Sciences.
I was a student in this course until March this year, and a paper containing the results of my research at that time has been accepted by an international journal. In fact, in the Fusion-of-Inteligence courses I took at K-SPRING, I was able to incorporate an objective perspective through discussions with course students from various fields, and I feel that I was able to apply this perspective to the writing of my paper.
A press release regarding this paper is available on the Kyushu University website. Please take a look if you like.
If you have any questions regarding our research, please feel free to contact us.
