プロテオーム解析によるマウス初期胚の全能性基盤要素の同定 Department of Systems Life Sciences, Graduate School of Systems Life Sciences 哺乳類ではたった一つの受精卵から個体が形成される。このように一つの細胞から一個体を形成できる能力を全能性といい、その性質を有する細胞を全能性細胞という。したがって全能性細胞は生命の源であり、その分子基盤を理解することは「生命とは何か」に対する知見をもたらす。本研究では着床前初期発生過程の細胞核を用いたプロテオーム解析から全能性制御に関与する要素の同定を目指す。
Investigation and Control of Multiscale Structure of Wavy Liquid Films on Wall Driven by Turbulent Airflow and Droplet Dispersal Phenomena Department of Aeronautics and Astronautics, Graduate School of Engineering As the demand for electric power increases, it is an urgent issue to improve the performance of generators. Steam turbines are used in thermal, nuclear, and geothermal power generation, and their impo [...]
The Recreative Process of Educational Culture by ：A Perspective on Life Culture Department of Education, Graduate School of Human-Environment Studies 1. 研究背景と目的/Research Background and Purpose In Japan, the intertwining of economic growth and the widespread adoption of modern public education has led to the marginalization of mechanisms that t [...]
Elucidation of the Regulatory Mechanisms Involving PRIP in the Gut-Brain Interaction Department of Dental Science, Graduate School of Dental Science The intestinal tract contains more than 1000 species and 100 trillion bacteria, which are constantly exposed to foreign microorganisms and food-derived antigens. Therefore, the intestinal tract has a [...]
Development of urban mines recycling process using hydrophobic deep eutectic solvents Department of Applied Chemistry, Graduate School of Engineering The objective of this study is to develop a reusable hydrophobic DES capable of selectively dissolving PGMs and to establish an environmentally friendly urban mining recycling process that eliminates [...]
Development of carbene-transfer reaction using dihydrogen as electrons source Department of Applied Chemistry, Graduate School of Engineering カルベンは反応性の高い化学種であり、それを反応に利用するカルベン移動反応では様々な有機合成が可能である。一方で、取り扱いが難しく環境負荷が大きい試薬の使用が問題点であった。本研究では、そのような試薬の代わりに水素から電子を取り出して反応に利用する新たなカルベン移動反応を提案する。将来的な目的物として、医薬品や天然物の有機物、精密合成による生成物などが考えられ、大きな社会的インパクトが期待される。
Comprehensive Analysis of the Pathogenesis of Propofol Infusion Syndrome Department of Medical Sciences, Graduate School of Medical Sciences Propofol is an intravenous anesthetic widely used for general anesthesia and sedation in intensive care, utilized in over 90% of scheduled surgeries in adults. However, high-dose, long-term administra [...]
In vitro reconstitution of the eukaryotic DNA mismatch repair in the context of chromatin Department of Systems Life Sciences, Graduate School of Systems Life Sciences DNA mismatch repair (MMR) is a mutation avoidance system that post-replicatively corrects nucleotide misincorporation errors. However, eukaryotic genomes are wrapped around histones to be assembled in [...]
