RESEARCH

カルベンは反応性の高い化学種であり、それを反応に利用するカルベン移動反応では様々な有機合成が可能である。一方で、取り扱いが難しく環境負荷が大きい試薬の使用が問題点であった。本研究では、そのような試薬の代わりに水素から電子を取り出して反応に利用する新たなカルベン移動反応を提案する。将来的な目的物として、医薬品や天然物の有機物、精密合成による生成物などが考えられ、大きな社会的インパクトが期待される。

Propofol is an intravenous anesthetic widely used for general anesthesia and sedation in intensive care, utilized in over 90% of scheduled surgeries in adults. However, high-dose, long-term administra [...]

DNA mismatch repair (MMR) is a mutation avoidance system that post-replicatively corrects nucleotide misincorporation errors. However, eukaryotic genomes are wrapped around histones to be assembled in [...]

Animal cells such as Chinese hamster ovary (CHO) cells have been utilized as producer host cells for the production of pharmaceutical proteins. However, the culturing of these animal cells requires la [...]

With the increasing ageing and various muscle diseases, more and more people are suffering from muscular weakness that makes them hard to cope with daily life. In order to solve this problem, we devel [...]

Sensory information from the periphery enters the spinal cord via primary afferents and is transmitted to the brain where it is perceived as various sensations. In the spinal cord, appropriate modific [...]

The detailed mechanisms that lowered the atmospheric CO2 concentrations by approximately 100 ppm during glacial periods remain a crucial open question. It is hypothesized that increased ocean alkalini [...]

Allylic amines are ubiquitous, prevalent in various biologically active compounds, and essential as synthetic intermediates for many organic compounds. We reported the first direct catalytic amination [...]

Development of carbene-transfer reaction using dihydrogen as electrons source

Comprehensive Analysis of the Pathogenesis of Propofol Infusion Syndrome

In vitro reconstitution of the eukaryotic DNA mismatch repair in the context of chromatin

Development of pharmaceutical protein production technology by transgenic chickens

Study on soft 7-DoF upper-limb power-assist robots

Study of immune cell infiltration into the spinal cord associated with spinal canal stenosis and the development of leg pain

Reconstruction of calcium carbonate dissolution and burial changes in the Southern Ocean floor during the past 140,000 years.

Convenient Direct Catalytic Synthesis of Primary Allylic Amines from Allylic Alcohols with Ammonium Acetate

“Future-Creation (MIRAI)” Course Kyushu University SPRING program