RESEARCH

ごく限られた細胞集団に特異的なエピゲノム情報を、DNA断片化を伴わず、更には多重に取得することを目指す。まず、特定のヒストン修飾特異的に反応するDNAメチル化酵素を創製し、一分子のDNA上にシトシンメチル化情報としてマーキングする。次にそのメチル化を長鎖シーケンスによって読み出し、所与のヒストン修飾情報を復元することを試みる。この技術を、発癌機序や起源が未知でありながら形態上の問題でシングルセル [...]

Undifferentiated embryonal sarcoma of the liver (UESL) is a rare liver malignancy. Origin and the development mechanism of UESL aren’t elucidated. In my research to date, p53−/− adult hepatic p [...]

COPD, Chronic obstructive pulmonary disease, is mainly caused by long-term smoking. It is one of the leading causes of death worldwide, affecting more than 5 million people in Japan. Recently, the pat [...]

As a next-generation energy source, the DT fusion reactor is expected to simultaneously solve the global energy demand surge and energy environmental problems. Because of its abundance in nature and r [...]

生物は微小な構成単位を集合させることによって材料を成し、集合構造に起因した優れた機能を創発させる。このプロセスは常温常圧、水系といった極めて温和な環境下で達成されることから、持続可能な社会の実現に向けて大きな注目を集めている。一方で、繊維状の物質は互いに絡まりあうため、複雑な構造を構築することが困難であった。本研究では、集合構造化の場として流体界面に着目し、ナノ繊維の緻密な構造化を通し、集合構造か [...]

Plants change their root structure in response to varying nitrogen (N) availability in order to utilize N in soil efficiently. The root of the model plant, Arabidopsis thaliana consists of a single ma [...]

This study uses stochastic frontier analysis to calculate the carbon shadow price and analyze the factors that affect the price. The carbon shadow price is the price to reduce carbon emissions by one [...]

Metal cyanide such as Prussian Blue Analogues (PBAs; MM’(CN)6) have been widely investigated due to its high designability and various functionality. It was known that various functions have those roo [...]

不均一な未分化型肉腫の長鎖エピゲノム解析を志向した新規解析手法の開発

Elucidation of development mechanism about undifferentiated embryonal sarcoma of the liver

Investigation of the effects of stretch stimulation in a COPD lung tissue model

Study on the Tritium Migration Behavior in the Systems of JA-DEMO Reactor

Interfacial architectonics of cellulose nanofibrils for induction of surface characteristics

Characterization of the Arabidopsis gene, SORFC03, involved in nitrogen-dependent lateral root development

The Comparative Analysis of Shadow Price of carbon using Production Function Analysis

The Control of Magnetic Transition Behavior of Ni(II) Center by Conjugation of Four-Coordinate Metal Cyanide

“Future-Creation (MIRAI)” Course Kyushu University SPRING program